Losartan can be taken by adults aged 18 years and over. Because no information is available regarding the use of losartan during breast-feeding, losartan is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant. If you take too many losartan tablets by accident, contact your doctor or go to your nearest hospital A&E department straight away. Losartan is predominantly metabolised by cytochrome P450 (CYP) 2C9 to the active carboxy-acid metabolite. Morning BP target (<135/85 mmHg) was achieved in 40.6% and 55.1% by combination therapy and in 14.7% and 24.2% by high-dose therapy in the Very-Elderly and Young/Elderly patients, respectively. Cardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interest (hyperkalaemia, hypotension and renal dysfunction) were more frequently reported in the aliskiren group than in the placebo group. Losartan should be used with caution in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Hypersensitivity to the active substance or to any of the excipients (see sections 4.4 and 6.1). Do not take a double dose to make up for a forgotten one. Each film-coated tablet contains 51.0 mg lactose monohydrate. Pharmacotherapeutic group: Angiotensin II antagonists, plain, ATC code: C09CA01. patients with severe heart failure or under treatment with high dose diuretics, † Common in patients who received 150 mg losartan instead of 50 mg, ‡In a clinical study conducted in type 2 diabetic patients with nephropathy, 9.9% of patients treated with Losartan tablets developed hyperkalaemia >5.5 mmol/l and 3.4% of patients treated with placebo, The following additional adverse reactions occurred more frequently in patients who received losartan than placebo (frequencies not known): back pain, urinary tract infection, and flu-like symptoms, As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function including renal failure have been reported in patients at risk; these changes in renal function may be reversible upon discontinuation of therapy (see section 4.4). Losartan starts to reduce high blood pressure after about 6 hours but it may take 3 to 6 weeks to fully take effect. The rise in trough diastolic blood pressure was the same in patients receiving placebo and in those continuing losartan at the lowest dose in each group, again suggesting that the lowest dose in each group did not have significant antihypertensive effect. The frequency of adverse reactions identified from placebo-controlled clinical studies and post marketing experience, Frequency of adverse reaction by indication, Hypertensive patients with left-ventricular hypertrophy, Hypertension and type 2 diabetes with renal disease, hypersensitivity reactions, anaphylactic reactions, angiooedema*, and vasculitis**, (orthostatic) hypotension (including dose-related orthostatic effects) ║, Respiratory, thoracic and mediastinal disorders, Musculoskeletal and connective tissue disorders, General disorders and administration site conditions, increased alanine aminotransferase (ALT) §, increase in blood urea, serum creatinine, and serum potassium, *Including swelling of the larynx, glottis, face, lips, pharynx, and/or tongue (causing airway obstruction); in some of these patients angiooedema had been reported in the past in connection with the administration of other medicines, including ACE inhibitors, ║Especially in patients with intravascular depletion, e.g. When losartan is administered orally, about 4% of the dose is excreted unchanged in the urine, and about 6% of the dose is excreted in the urine as active metabolite. The starting dose is 50 mg losartan/12.5 mg hydrochlorothiazide or 100 mg losartan/12.5 mg hydrochlorothiazide, taken once per day. Losartan was given at doses of 0.7 mg/kg to 1.4 mg/kg (up to maximum dose of 100 mg per day). 722 patients over 65 years old with New York Heart Association class II-IV heart failure and ejection fractions less than 40% were randomised to losartan or captopril. I even got light-headed when I stood up quickly. Arrow-Losartan potassium and Hydrochlorothiazide may be administered with or without food. Can I take losartan to protect myself against Alzheimer's disease? Losartan dosing information. But if your condition doesn't improve, your doctor might try losartan. The amount of losartan that can lead to an overdose varies from person to person. The primary endpoint of this prospective study was the all-cause mortality. There is no therapeutic experience in patients with severe hepatic impairment. Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. The dose should generally be titrated at weekly intervals (i.e. The antihypertensive effect of losartan was established in a clinical study involving 177 hypertensive paediatric patients 6 to 16 years of age with a body weight > 20 kg and a glomerular filtration rate > 30 ml/ min/ 1.73 m2. To bookmark a medicine you must sign up and log in. Usual Adult Dose of Losartan for Diabetic Nephropathy: Initial dose: 50 mg orally once a day. Losartan is a medicine widely used to treat high blood pressure and heart failure, and to protect your kidneys if you have both kidney disease and diabetes. Other antihypertensives, with the exception of ACE-inhibitors, angiotensin II antagonists or beta-blockers were added if necessary to reach the goal blood pressure. In both comparator-controlled (not placebo-controlled) clinical studies on patients with heart failure the tolerability of losartan was superior to that of captopril, measured on the basis of a significantly lower rate of discontinuations of therapy on account of adverse reactions and a significantly lower frequency of cough. Not recommended ( see section 4.3 and 4.4 ) also help if you have coronavirus, a... And may need medical attention 50 mL/min, respectively within three days to the active are. Some samples contained traces of a similar chemical ( NDEA ) in batches of losartan ACE-inhibitors. And undergoes first-pass metabolism, forming an active carboxylic acid metabolite and other inactive metabolites are formed to your... 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